As part of the Human Genome Project, a total of 24 distinct human chromosomes were sequenced. In a human cell, there are indeed 46 chromosomes, consisting of 22 pairs of autosomes and one pair of sex chromosomes (XX in females, XY in males). However, when referring to the number of chromosomes sequenced in the Human Genome Project, it is often stated as 24. These include 22 pairs of autosomes (numbered 1 to 22) and one pair of sex chromosomes (X and Y). Therefore, the total count of distinct chromosomes in the human genome is 24.